DRUG DISCOVERY

DRUG DISCOVERY

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How new medications are discovered

Drug discovery is the process how new medications are discovered. In history, drugs were mostly found by identifying active ingredients from traditional medicines or purely by chance. Afterward, classical pharmacology was used to investigate chemical libraries including small molecules, natural products, or plant extracts, and find those with therapeutic effects. Since human DNA was sequenced, reverse pharmacology has found remedies to existing diseases through testing.


Disease processes, molecular compound tests, existing treatments with unanticipated effects, and new technologies spur drug discovery through the cycle below.

Today drug discovery involves screening hits, medicinal chemistry, and optimization of hits to reduce potential drug side effects (increasing affinity and selectivity). Efficacy or potency, metabolic stability (half-life), and oral bioavailability are also improved in this step of the drug development process.

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High Content Screening (HCS)

High content screening (HCS) has played a significant role in infectious disease research and drug discovery to date and can be a strong tool in the age of COVID-19 and beyond.

With a focus on viral diseases, HCS has been used by laboratories around the world to help with three key interventional strategies:

HIGHLIGHTS

  • Drug re-purposing to fast track previously approved drug to treat new diseases
  • Development of new therapeutics and
  • Vaccine development.
 

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Image Annotation Workflow

With the development of diagnostic imaging devices, large amounts of digital high-res and 3D images are generated every day. The requirements of effective indexing and searching image are growing rapidly. Image annotation is an effective way for content-based image retrieval.

HIGHLIGHTS

  • Semi-Automatic operator supported models
  • Automatic annotations with AI
  • Manual annotation (remote, mobile devices)
 

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Remote Image Analysis

When researchers start to collaborate over distances with imaging centers, using diagnostic services over internet connections the bandwidth and computation power easily exceeds the capabilities in remote areas.

HIGHLIGHTS

  • 3D organotypic culture models
  • Microplates
  • Automation and liquid handling
  • 3D imaging
  • 3D image analysis
 

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Laboratory RAW Data Management

RAW DATA in laboratories occur in various fluctuating formats and versions in a large amount of laboratory devices, LIMS and quality management systems. Handling and traceability along the whole life cycle are key to lab control and end-to-end compliance in the drug development process.

HIGHLIGHTS

  • OOS Tracking
  • Archiving
  • Long term file formats
 

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CRO Collaboration

The last few years have seen tremendous consolidation in both the pharmaceutical and contract research industries. The impact among pharma companies has created a heightened demand for productivity. Properly designed CRO Collaboration opens capabilities in various functions like the following:

HIGHLIGHTS

  • Pharmacovigilance
  • Medical Writing
  • Statistical Programming
  • Site Management
  • Regulatory Affairs
  • Regulatory Operations
  • Biostatistics
  • Data Management
  • Translational Medicine
  • Medical Affairs
  • Clinical Monitoring
 

iRAW


intelligent raw data archiving watcher
RAW Data, GxP Lab, Controls, SEND, loT

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ARC+

IMAGE+
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As well as all other Add-ons ...

iPQM


intelligent pharma quality management
QMS, qDMS, CAPA, Image QC, Issue Management

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SIGN+
IMAGE+
BYOD+
BRAIN+
TRAIN+

As well as all other Add-ons ...

iTMF


intelligent trial master file
DIA eTMF, CRO Migration, Longterm Archiving

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BRAIN+
REPORT+
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TRAIN+
COMPLY+
MIGRATE+

As well as all other Add-ons ...

iRCS


intelligent regulated content services
rDMS, RIM robot, IDMP/SPOR, promo mats

COMPLY+

WATCH+
ARC+
REPORT+
BRAIN+
SIGN+
TRAIN+

As well as all other Add-ons ...

CUSTOMERS

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“ The only way to discover the limits of the possible is to go beyond them into the impossible.”